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Via Arstechnica:

This week, Lavis and his colleagues reported in Nature Methods that they have come up with a tunable way to create bright, stable, cell-permeable dyes in any color a researcher could want.

The advance is an improvement on a class of dyes called “rhodamines.” Although his lab has been working on it for several years, he tells me, it’s an improvement that’s been in the making for over a century.